{"id":1131,"date":"2023-02-22T17:04:45","date_gmt":"2023-02-22T10:04:45","guid":{"rendered":"http:\/\/bangkokmedica.co.th\/?p=1131"},"modified":"2023-03-27T12:24:16","modified_gmt":"2023-03-27T05:24:16","slug":"a-probiotic-prebiotic-combination-reduces-behavioral-symptoms-associated-with-stress","status":"publish","type":"post","link":"https:\/\/bangkokmedica.co.th\/en\/a-probiotic-prebiotic-combination-reduces-behavioral-symptoms-associated-with-stress\/","title":{"rendered":"A Probiotic\/Prebiotic Combination Reduces Behavioral Symptoms Associated With Stress"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1131\" class=\"elementor elementor-1131 elementor-323\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9052061 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"9052061\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d017433\" data-id=\"d017433\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-63d4464 elementor-widget elementor-widget-heading\" data-id=\"63d4464\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">A Probiotic\/Prebiotic Combination Reduces Behavioral Symptoms Associated With Stress<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-912b3f8 elementor-widget elementor-widget-post-info\" data-id=\"912b3f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-10f2194 elementor-inline-item\" itemprop=\"author\">\n\t\t\t\t\t\t<a href=\"https:\/\/bangkokmedica.co.th\/en\/author\/webmaster\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-user-circle\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\twebmaster\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-005d390 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/bangkokmedica.co.th\/en\/2023\/02\/22\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-calendar\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>February 22, 2023<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-a83d5d7 elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-clock\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-time\">\n\t\t\t\t\t\t\t\t\t\t<time>5:04 pm<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-89ff28a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89ff28a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ec6e73b\" data-id=\"ec6e73b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f305187 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f305187\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5474f81\" data-id=\"5474f81\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-89ef575 elementor-widget elementor-widget-image\" data-id=\"89ef575\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/bangkokmedica.co.th\/wp-content\/uploads\/2023\/02\/probiotics-1.jpg\" class=\"attachment-large size-large wp-image-996\" alt=\"\" srcset=\"https:\/\/bangkokmedica.co.th\/wp-content\/uploads\/2023\/02\/probiotics-1.jpg 800w, https:\/\/bangkokmedica.co.th\/wp-content\/uploads\/2023\/02\/probiotics-1-300x225.jpg 300w, https:\/\/bangkokmedica.co.th\/wp-content\/uploads\/2023\/02\/probiotics-1-768x576.jpg 768w, https:\/\/bangkokmedica.co.th\/wp-content\/uploads\/2023\/02\/probiotics-1-350x262.jpg 350w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2dc9bd2\" data-id=\"2dc9bd2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8e1891b elementor-widget elementor-widget-heading\" data-id=\"8e1891b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">A Probiotic\/Prebiotic Combination Reduces Behavioral Symptoms Associated With Stress<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3741a9 elementor-widget elementor-widget-text-editor\" data-id=\"a3741a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">A synbiotic (a probiotic plus a prebiotic) can reduce behavioral symptoms associated with stress by normalizing the populations of microorganisms in the gut and changing immune cell activity, according to a new study in animals from Icahn School of Medicine at Mount Sinai, and the James J. Peters Veterans Affairs Medical Center, New York. The study was published in <\/span><i><span style=\"font-weight: 400;\">Frontiers in Immunology<\/span><\/i><span style=\"font-weight: 400;\"> and supported by the National Center for Complementary and Integrative Health and the National Institutes of Health (NIH) Office of Dietary Supplements through the<\/span><a href=\"https:\/\/ods.od.nih.gov\/research\/Dietary_Supplement_Research_Centers.aspx\"> <span style=\"font-weight: 400;\">NIH Consortium for Advancing Research on Botanical and Other Natural Products (CARBON) Program<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-21196ae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"21196ae\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5e058e6\" data-id=\"5e058e6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eb97427 elementor-widget elementor-widget-text-editor\" data-id=\"eb97427\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">The gut-brain axis refers to the bidirectional communication between the emotional and cognitive centers of the brain with peripheral intestinal functions. Gut microbiota has been shown to influence these interactions. Previous research has also shown that substances that change the community of microorganisms (the microbiota) in the intestines can reduce behavioral symptoms associated with stress. These substances include probiotics (live microorganisms that are intended to have health benefits when consumed or applied to the body) and prebiotics (nondigestible food components that selectively stimulate the growth or activity of desirable microorganisms). How probiotics and prebiotics produce effects in the body is not well understood, but it may involve changes in inflammation and immune responses associated with changes in the gut microbiota.<\/span><\/p><p><span style=\"font-weight: 400;\">This study evaluated the effects of a synbiotic that included two bacterial strains (<\/span><i><span style=\"font-weight: 400;\">Lactobacillus plantarum<\/span><\/i><span style=\"font-weight: 400;\"> ATCC 793 and <\/span><i><span style=\"font-weight: 400;\">Bifidobacterium longum<\/span><\/i><span style=\"font-weight: 400;\"> ATCC 15707) and a prebiotic composed of grape seed polyphenol extract, resveratrol, and concord grape extract. Previous research had shown that this prebiotic has neuroprotective effects and that the effect of its polyphenols is greatly enhanced when it is administered together with probiotics. (Polyphenols are substances found in many plants that have antioxidant activity.)<\/span><\/p><p><span style=\"font-weight: 400;\">In this study, mice were randomly assigned into eight treatment groups including untreated control, prebiotic-only, probiotic, or synbiotic, and each treatment group was treated with one condition, either stressed or non-stressed. The researchers found that the probiotic and the synbiotic decreased depressive-like behavior compared to the control group following chronic unpredictable stressors. All treatment groups had a beneficial effect on anxiety-like behavior following chronic and recurrent stress. Overall, the synbiotic promoted more consistent and robust resilience to stress-induced behavioral impairments compared to its components. In addition, at the gene level, the synbiotic, but not the probiotic or the prebiotic, reduced inflammatory gene expression profiles. Importantly, the immune cell recruitment genes, <\/span><i><span style=\"font-weight: 400;\">Ccl2, Ccl5,<\/span><\/i><span style=\"font-weight: 400;\"> and <\/span><i><span style=\"font-weight: 400;\">Icam,<\/span><\/i><span style=\"font-weight: 400;\"> were the most consistent and drastically impacted factors by both stress and the synbiotic, paralleling the behavioral response. This suggests that the recruitment of peripheral immune cells into the brain may be important for triggering the gut-microbiota stress-induced behavioral responses.<\/span><\/p><p><span style=\"font-weight: 400;\">The researchers also found that the synbiotic was the most effective at normalizing the changes in gut microbiota diversity caused by chronic and recurrent stress. In addition, the investigators developed a machine learning algorithm to examine associations between chronic and recurrent stress, gut microbiota composition, and inflammatory markers in a way that considers variations among individuals and the synergistic activities of the brain and the rest of the body. Primary associations between the gut microbiome and behavior included <\/span><i><span style=\"font-weight: 400;\">Lactobacillus<\/span><\/i><span style=\"font-weight: 400;\"> and <\/span><i><span style=\"font-weight: 400;\">Ruminoclostridium<\/span><\/i><span style=\"font-weight: 400;\"> spp., while the interaction of <\/span><i><span style=\"font-weight: 400;\">Lactobacillus<\/span><\/i><span style=\"font-weight: 400;\"> with either <\/span><i><span style=\"font-weight: 400;\">Faecalibaculum, Blautia,<\/span><\/i><span style=\"font-weight: 400;\"> or <\/span><i><span style=\"font-weight: 400;\">Bifidobacterium<\/span><\/i><span style=\"font-weight: 400;\"> spp. produced significant secondary associations. The researchers also found that <\/span><i><span style=\"font-weight: 400;\">Lactobacillus spp<\/span><\/i><span style=\"font-weight: 400;\">. improves barrier immunity, while <\/span><i><span style=\"font-weight: 400;\">Lactobacillus<\/span><\/i><span style=\"font-weight: 400;\"> and <\/span><i><span style=\"font-weight: 400;\">Bifidobacterium<\/span><\/i><span style=\"font-weight: 400;\"> supplementation in aging mice improved barrier function, reduced peripheral inflammation, and improved cognitive performance.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-822221a elementor-widget elementor-widget-heading\" data-id=\"822221a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Reference<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b8da398 elementor-widget elementor-widget-text-editor\" data-id=\"b8da398\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Westfall S, Caracci F, Estill M, et al.<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34248950\/\"> <span style=\"font-weight: 400;\">Chronic stress-induced depression and anxiety priming modulated by gut-brain-axis immunity<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><i><span style=\"font-weight: 400;\">Frontiers in Immunology.<\/span><\/i><span style=\"font-weight: 400;\"> 2021;12:670500.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e3d97b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8e3d97b\" data-element_type=\"widget\" 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class=\"elementor-share-btn__title\">\n\t\t\t\t\t\t\t\t\t\tPinterest\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_email\" role=\"button\" tabindex=\"0\" aria-label=\"Share on email\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<i class=\"fas fa-envelope\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-share-btn__text\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__title\">\n\t\t\t\t\t\t\t\t\t\tEmail\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1f7524 elementor-share-buttons--shape-rounded elementor-grid-mobile-0 elementor-hidden-desktop elementor-hidden-tablet elementor-share-buttons--view-icon-text elementor-share-buttons--skin-gradient elementor-grid-0 elementor-share-buttons--color-official elementor-widget elementor-widget-share-buttons\" data-id=\"a1f7524\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_facebook\" role=\"button\" tabindex=\"0\" aria-label=\"Share on facebook\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<i class=\"fab fa-facebook\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_twitter\" role=\"button\" tabindex=\"0\" aria-label=\"Share on twitter\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<i class=\"fab fa-twitter\" aria-hidden=\"true\"><\/i>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_pinterest\" role=\"button\" tabindex=\"0\" aria-label=\"Share on pinterest\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<i class=\"fab fa-pinterest\" 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